My group is between 6 and 10. It helps that we have established relationships outside of gaming so we can take social ques in-game right off the bat. For instance, the game includes one woman, her husband, her son and her granddaughter. With that dynamic already established, getting a bead on how to keep my players engaged and how they can keep me focused is determined before we sit down to the table.
It also helps that I am a madman about preparation. Shadowrun is a sandbox game is ever there was one, especially with creative players and so many avenues of man, magic and machine to travel down. Knowing your players and establishing a baseline of what will go down when given the many options available is a must for that many people.
A double-edged sword is that most of my players don't know and aren't too keen to learn the rules. Not just "Does threading take an action?" rules, but "What do I roll to shoot things?" rules. While this can be a thorn in my side on multiple occasions, it does help by establishing what kind of game we want to play. We never waste our time debating whether or not hardliner gloves add to unarmed adept powers or whether they can make unhackable commlinks, because these things aren't entirely academic to my players. This means I get to spend more time describing the world and the people who live in it and less time describing the specifics of range penalties.
Now, I don't recommend playing with people who don't want to read more than a few paragraphs of the book, but it is helpful to decide things like Explosions in Space and Mario v. Improv before the game begins.
Mostly I like running for such a large group because it is diverse. We have people from age 16 to 60+, three Census ethnicity form boxes and mostly girls. Not my normal gaming experience. This leads to a diverse exchange of different experiences, ideas and thought processes that reflect the kind of diversity that would come from a group of ork mercs, human mages and elven technomancers.
I might not play something like Paranoia or CoC with that many folks, but for Shadowrun I say the more the merrier.