Still trudging my way through the 4th Ed books, missing a lot of background info, (If anyone could provide a start-to-finish reading order, so I'd have the ENTIRE story, I'd be grateful, even if my pocketbook wouldn't.) but I think it's safe to say that TMs are going to become more and more 'different' from Hackers and Magicians. Currently, they're a Copy Paste of Magicians, but diverted to the Matrix, which is treated kind of like the Astral. Both are overlapping, etc. The mirror image concept is unlikely to continue.
Magic, by its nature, is going to be more prevalent. As the Mana levels rise, the Horrors come closer. In the same stream, Metahumanity will be able to draw on more and more, and will continue to evolve in ways previously unseen.
Given that the Orange Queen is going to be Running to make ends meet, I think we'll see an awful lot more of her, on a street level.