Last session, I have a trio of decked-out prime runners (we're talking 500 BP + karma and gear to match) against the runners and, short of soak rolls (where they reliably averaged 7 or 8 hits), they couldn't get more than 2 hits on anything, even with 16+ dice pools.
That combat was painful, it dragged out so much, neither side landing a meaningful hit for a good while. Finally, the NPC troll cyber-naut was taken down (at least 3 rounds from the team's sniper + close-in support + Stick-N-Shock before he crashed). This gave me an excuse to have the mage run in terror (she'd already taken a short-burst of capsule rounds loaded with CS Gas). The melee-adept surrendered when faced with the full force that had taken down his decked-out troll partner.
Did I mention that the actual runners were netting 4+ hits on everything? I almost wish the soak rolls had been as bad as the dodge, spellcasting, attack, and perception rolls.