I've been combing through all of my sourcebooks lately in preparation for paper I'm writing for a game design course, as well as brushing up on various forums, and there are a few pieces from the most recent sourcebooks that just fit together too nicely. So there's a lot going on and the chips could fall in a lot of ways, but the fact that these few things seem to be linked, and that, collectively, they have been appearing more often in the books (and especially on the tarot cards) leads me to believe that the big 5th ed culmination metaplot (in line with the Chicago fiasco, Crash 2.0, and the Great Dragon Civil War) is going to see the food crisis burst open in Asamando, resulting in ghoul cannibalism that results in some sort of Horror-based threat (who they seem to be rebranding as the Elder Gods so they can use them again).
The whole bringing back and updating the Horrors, I think, would click well with an overarching nostalgic theme that seems permeate 5th ed (bug spirits coming back to the fore, Deus showing up in Boston - essentially a different spin on old shit, which, so far, I've loved). On top of that, we've recently been seeing updates on, right alongside the Elder God stuff, more action and activity from bug spirits and the shedim, who have historically been indicators that the Horrors are drawing closer to our metaplane.
Then, working back from there, Forbidden Arcana has a full chapter that pretty closely ties Ordo Maximus to the Elder Gods (whether they know it or not), and seems to imply a connection the HMHVV virus has to them that can either be strengthened or brought out via ghoul cannibalism.
And then on top of that, an incipient food crisis has been looming over Adamando for a while now. The thing that really sold it for me was an image I came across earlier (it's old news by now, but I'm not sure how widely known it is) that demonstrates if you line up the bottoms of the minor arcana in a sixth world tarot deck correclty, the little dots at the bottoms create a map of the world. If you do it with the aces, the court cards, and the major arcana, same deal, except the dots are arranged so that there is clearly a ring rippling out into the world. And wouldn't you know it? The epicenter of that ring is right in the middle of Asamando.