The most interesting, exciting, world changing moments and events in SR5 all seem to be delivered In shadowtalk, with the honourable exception of Lockdown.
There really hasn't been any world impacting 'adventure' books other than Lockdown - - neither pure adventures like we saw back in the early days with things like Universal Brotherhood, nor adventure ideas books like we saw in SR4 with the artifacts and Horizon books for example.
I can't tell you how pleased I was that there was one adventure stuck into the Seattle boxed set, nor how frustrated I've been with the number of cool and exciting things I've read about in shadowtalk that would have made great adventures to run in game.