high powered is just that you put 20% more propellant into the same round (which does not become a magnum round jsut by that) which is problematic because it can destroy your weapon... if it doesn't the muzzle velocity and therefore the kinetic energy of the projectile is greater...
to counter the "my weapon will explode" you can mod your weapon to withstand the increase in propellant... that's the the mod.,..
when not using the mod:
other games handle it like 1/5th chance that your weapon explodes with high powered rounds... I'ld go with 1/6 because we only have d6 or leave it to handle it like a test with gremlins 3 (count 3 more 1s and if it goes bad it'll explode)...
all in all though you could theoretically high power every round you want (especially no problem for AV, hollow point or the like which is basically still a solid metal(or other durable material) round)
it could of course get really problematic with capsule rounds, explosive rounds, and I really don't know about the disposable sabot... maybe it get's blasted to pieces before it does it's thing
that of course is only to the extend of my knowledge and by no means RAW