The game doesn't really due the "just die" thing very often. Especially not with anything readily available (all I can think of is radiation exposure and pretty much close hits with a Thor Shot). Most of the toxins in Arsenal are far, far, far less powerful than they should be just to maintain balance. SR4 rules are, without a doubt, an action movie. The good guys always survive the ridiculously lethal attacks (I seem to remember one surviving a nuke blast with a refrigerator not too horribly long ago).