Like I said before, in Shadowrun the goal shouldn't be 'kill everything' but 'GTFO of Dodge'. You do enough to accomplish the mission and get out. Tactics become very important. Tossing flashbangs into a room before you breach in order to soften up the guards, spraying bullets to keep people's heads down while you escape, killing the lights, sealing doors behind you, diving off the cliff to the boat waiting below, and so on. But my inspiration for shadowrun comes primarily from sources such as James Bond, Johnny Mnemonic, Hackers, Ghost in the Shell, and the like. In other words, most of the time stealth, planning, and guerilla tactics are more important than blowing the hell out of things.
It's just as equally important in Dnd. If you see an group of my firebusters. (red orcs) your not going to rush them, (or fire ball them for that matter) Your going to need to use tactic's to gain the initial upperhand, and if your doing a mission to obtain something from them or the Zhentarim you don't want to go exploring every damn room in the 4 floor dungeon, you'll never make it out alive. Don't make too much noise in the dungeon or you have to worry about flankers, if someone got away assume they are going to sound the alarm just like an alarm in the building. Beware of Invisible stalkers, or eyes on the walls, there are plenty of things in dnd that is just like Shadowrun.
I'm failing to see the fine point. I get that shadowrun is supposed to be deadly but it's still tailored to be advantagous to the player. There are plenty of things you can do to get you killed in Shadowrun, just like there are plenty of things that will get you killed in DnD. They are different because the settings are different sure, and I agree you don't want to stick around but from what you can do in shadowrun you can easily take down most opposition really quickly.
Your first sentance is also true of Dnd. Your first objective should not be kill everything, that is a way to garentee you'll make a lot of enemies in DnD.