Iran Lockdown, but not strictly by the book. First of all iwas running it for a single player (a shaman), so naturally that requires tweaking some things (he was working with some less capable NPC, but I tended to handwave most of the matrix stuff, for example). And iruled that five hits on assessing was enough to tell if someone had substantial Nantes in their system (wouldn't confirm CFD, but given the environment...)
For food, survival, security I tended to run one scene to establish a reasonable solution, then just role played it from there as things got tenser,. I.e. early on he made good relations with Four Corners, such that they would trade him food for goods or favours, only played the first scene out in detail, after that just talked through what had changed when he went back every couple of days). Once they had worked out their travel solution of an electric van running just a bit above running speed (for quietness and charge efficiency) I didn't make most travel too hard, just the occasional unusual event (new checkpoint, seeing an incident, etc), that allowed us to mostly play the plot while still showing a bit of how things were valving in the city.
I deviated more towards the ending. I made the rumoured dragon Ash a dragon th PC had interacted with in Seattle, and he ended up Mr. Johnson - ing a couple of the later runs. Around the time all the offers came in a mad Evo scientist launched an assault on their safe house, and they got hints of others trying to scoop them up, and they were attacked while trying to move to a new location.
Then Ash found them and said he was planning to leave the city, and if they would give him all the info they had gathered, with a 45 day exclusive use period, he'd take them out with him. So the choice was between all the money, promises of investigations ... or a escape from he'll. was a pretty easy choice.
PC and friends protected Ash while it prepared some magics, then it used the dragon let line to achieve a sufficient mix of invisibility, speed, and altitude to make a run for it. (Runners barely survived as they didn't realize that scuba gear doesn't help you breathe at high altitudes much, but were still clinging to life when they were dumped in the middle of feuding families in the Adirondacks).
Lots of ways to use what is in that book, that was my solution.