Overall-
On the plus side
5th ed is much easier to introduce a new player to. Its still crunch heavy but build points in 4th ran off some players of mine. They literally looked at the core book and said no way, I am not going to the trouble of learning that.
I think the core mechanics of 5th, including the changes to decking and the minor changes to magic, are very sound. I would rather play those than 4th. With the occasional house rule to patch omissions in the rules, its certainly playable.
On the negative side-
Editing and production quality are inconsistent. Core book is ok if you get the 2nd printing, I think Run Faster and Run and Gun were reasonably well done. Street Grimoire was more iffy, but it has a bunch of traditions and a expended spell list, which is nice to have. It completely lacked some thing that some people were expecting, such as rules for custom spell design or even just inventing formulas for known spells from scratch. Other sections were simply. . . puzzling, both in their mechanical implementation and how they would actually affect a game.
The last two main books, Data Trails and Chrome flesh (I have data trails, chrome flesh I have not seem yet, but I have heard multiple reports) are fluff bombs. I was deeply disappointed in Data trails, both in the amount of useful material that was actually in it, its almost non-existent table of contents and complete lack of an index, and the fact that areas that needed some real mechanical love, like technomaners, got almost no attention. I don't know how much hard rules are actually in Chrome Flesh, but I am hearing the same thing, tons of jackpointer fluff, meaningless TOC,, and yet again no index.