First note, I have not, in detail, read this entire thread. 12 pages is allot to read in 1 sitting. My wife sent me this link as most of my games over the past 25 years have been "High Concept" (Shadowrun, Star Wars d6, Cyberpunk, D&D, Mutants and Masterminds, TMNT, Rifts, Star Trek, Call of Cthulhu, Warhammer Fantasy, Palladium Fantasy, D20 Modern, allot more I can't remember off the top of my head and about a dozen or so most of you probably haven't even heard of).
One player in my current campaign (before he moved away) was fascinated with Deadpool. He had the personality to pull off playing him too. Now I allowed him to play an "inspired" by Deadpool by letting him have critter Regeneration. Tool all 5 power points he had, but he was cool with it. Room to grow. It was a BLAST! All of his IC commentary was perfect, the other players love him (between laughing and holding face in palm) and Regeneration, while I was VERY iffy about it at first, really wasn't half as overpowered as I feared.
Now my current campaign (2 1/2 years running now) is very High Concept. One might even say Epic. Dealing with metaplots, crossed universe concepts, the whole shebang. Part of the fun to me.
To me, this is the best way to run. My players agree. Hell, they even tried to take Munchie Run up a notch. lol