Tasti man, I am curious: are you restricting yourself just to the corebooks? If so..then:
Vampire: The PCs are Neonates in a Camarilla city at war with the Sabbat. They are starting off with a simple
job: cover up the Masquearde breeches of the Sabbat. Over time, they begin to notice a pattern and figure out
that someone inside the Camarilla is leaking the Sabbat information. Who is it? How can they do something
about it, as they likely do not have the same Status as their suspect, who can just use his/her status as a shield
against these Neonates. And so, they have to begin working against him subtly, plotting, planning, until they can
make his enemies have an excuse to move against him.
Werewolf? Take a city, look at the threats to natural things in it..make those supernatural threats. Your Werewolves
are a pack working to stop those, and defend their Caern. Or maybe they are dealing with a subtle threat. Start out
with a grissly murder of some Kinfolk. The Elders won't deign to send a more experienced pack on it, because,
after all, these are merely Kinfolk..so the player's pack gets that task. As the investigate, the find more subtle things
going on, and find a link between these kinfolk and that battered woman's shelter that opened a couple months ago.
And it just gets darker from there, leading, ultimately, to some major Bane that is manipulating everything to try and
cause the Wolves to turn on each other.
These are the only ones that have their 20th anniversary books out. Mage is still in writing, so I would not say that that
won't provide similar great hooks, and Changeling is not going to be touched until next year.