Here's an idea I've bounced in my skull awhile: some rich, eccentric (totally loony) but harmless schmuck, probably living a Full Immersion lifestyle surrounded by these types of program icons and fantasies, wants to have some meatworld fun. He hires a team of runners to be on retainer, and has his (exasperated) employees help. They doll the runners up in full superhero attire, and he lives out his fantasy by paying the characters to go be real-world Four-Color Superheroes in a world where that idea just doesnt work.
In the end, maybe it falls apart because its a horrible idea. Maybe the team decides they like being Big Damn Heroes. Or maybe he's not really delusional, and an epic PR scheme turns them into well-known public figures as part of a bigger plan (noble or sinister).
Which brings up other questions. In a world as fantastic as SR, would comics even survive? So many powers would now be really possible. And what comic good guys would be easy to replicate with SR4 chargen?