I've been running season two and it can support a fair amount of, we'll call it taking the scenic route. I can't talk on the next two seasons very much other than saying they have much better production quality, but season two is very very easy. Even if you use the New Table Rating system from Season 3 (which I recommend highly if you have experienced players), anyone with a half way decent head at making characters will walk through the opposition with no issues until the last four or five missions of the season, and even then it's more like a speedbump rather than the slight gust of wind that came before. Just to be absolutely clear what we're talking about here, most of the statted badguys seem to be on par with the Weapons Specialist archetype.
If you have a smart group that is well balanced (I have a smart group with a Hacker, Mage/Face, Phys Ad, Sniper, and Street Sam), expect them to come in with far more nuyen than the "payout" either through simple greyhawking of everything (Greyhawking- Verb. To loot everything remotely possible of being sold later from a scene/body/bodies.) or smart planning (stealing corporate trucks/supplies, stealing that ridiculously high powered Rating 10 Software, etc.). Likewise, it's extremely easy for the Hacker to get way ahead of the rest of the group on the nuyen scene just because of the amount of paydata/software available that is, when it comes down to it, almost always just up for grabs if the hacker is remotely capable or has decent edge (god forbid their extremely capable and have high edge, because then they'll be able to do anything. Trust me.).
For the most part, the missions I've run are pretty easy to go. They have only a couple vital scenes, the meet, the target, and sometimes and inevitable trace/combat scene. The other scenes are just suggestions for how the players can get there, and if you have time you can drag things out as long as it's fun.