To those of you have read/run Ghost Cartels: What are the especially nasty spots I should watch out for to avoid an unecessary/unfair TPK?
I've run the Seattle part of Ghost cartels this far. I usually had a core team consisting of a hacker, social adept and "gimme heavier weapons"-Sam. There are sometimes more people, as in a mage, an even more dangerous Sam and a support character - lots of skill groups, almost no fighting ability.
Problematic were the two adventures in which Chikao Inoue was in (Yakuza team leader with Edge 8 and cyberarms Agility 9). He can end up accidentally killing the entire team.
Luckily, my players got the hint rather fast when the Street Sam started edging his shots at him and kept missing.
Also, the possessed Jose Vilamoura (adventure is still in the seattle timeframe, but in the "Source" chapter after Seattle) is one damned dangerous statmonster. I ended up playing him as more interested in addicting the characters to tempo than killing them (would have probably been a TPK).
From reading forward, I'm guessing that the defense mission in Hong Kong (The Kowloon Massacre) is going to be ugly. Brutal background count is really hindering mages/adepts, about one third to a half of the areas with BC is going to be aspected towards a magician/Yama King and I'll have endless reinforcements to throw against the players. They'll run out of ammo before long.
In Retributive First Strike (also Hong Kong), the team might get the idea to steal a freighter rather than to destroy it (mainly because a NPC tells them it's a rather expensive ship before factoring in the cargo).
The opposition on board (Shedim) can really tear teams without magical or heavy weapons support to pieces.
Later (back in the UCAS and South America), you'll get opposition like the cybered adept with magic rating 10, which can really turn your whole evening into a slaughter-fest.
I recommend giving out as much karma as you can, following the SR4A guidelines. My players are wondering WHY I'm doing that - they are more used to SR1/SR2 Karma, which was substantially lower.
And most importantly, have fun.