Hmm...seems best for a oneshot, though a skillful gamemaster and merciful players could probably work with it; how about the usual goals of extraction and data recovery, but have one (or more) players be at cross purposes; eliminate witnesses, destroy surveillance, return data? Or I suppose there could be an open counteroffer...which seems to lead into game theory if the regular run is more lucrative in total but the treacherous one is more lucrative for the traitor.
I'm also considering having the players meet up on separate missions, possibly with a mexican stand off, for the in medias res. Maybe they've met before, maybe not.
This sounds like it calls for higher BP, more experienced runners.
EDIT: and possibly have one person to record a reality tv show, suitably edited, like that story in SR4Anniversary.