With Chrome flesh, there are now two ways to overdose on drugs. The Core book has you take damage if you use two drugs that effect the same stat. Chrome Flesh has you roll on a chart whenever you take two drugs. Normally, I would use the most recent ruling. When running Missions, the question is are we using the Core rules, the Chrome Flesh rules, or both. If both, then we are adding quite a bit of penalty to using chems. So, which option are we using? It isn't addressed in the FAQ.
I apologize if this has come up before, but Search isn't working and I didn't see it myself.