That's a perfect example of why you shouldn't use Set-up. You'd be better off simply hitting your opponent. For one thing, Set-up is your attack so it eats the Counterstrike bonus. Second, even if you get a bigger bonus from Set-up, it's probably not enough bigger to offset the penalty your opponent would have gotten as a Wound Modifier if you hit them instead. Third, you might just knock your opponent out anyways.