Anything, but what they did with 7th Sea 2e and Vampire 5e. I don't want a totally different game than Shadowrun is right now, I'm content with it being the game it is, yes with all the dices and crunchiness (but I'm happy for anarchy to exist for people who like that style).
I'd be happy with a 30th anniversary, with some cleanup of the rules, to be honest. Maybe a big, comprehensive 6th World setting book.
That, or a real-life Lofwyr plushie...