Thematically it's still the Colt Manhunter, 2050s version, 2070s version or otherwise. It may not have quite the bells and whistles, and it's not the Savalette (but then, I kind of wish the Savalette had some situational drawbacks) but damn if it isn't a nice hunk of iron. ever since I first ran into it in the Street Sam Catalogue for SR2, I've liked the looks.
The fact that it's the weapon of choice for Dirk Montgomery (and I have a soft spot for the character and Nigel's work in general) helps too.