I imagine I could have a lot of fun with Wuxing. I live in China right now, and as tied up their corporate cultures is going to be in Chinese alchemy and numerology, they could almost serve as comic relief for me and my buddies over here, though sometimes I can have them do stuff that's crazy in a frightening way. Upcoming run will see them fighting a Triad squad (not Wuxing, I know, but they subscribe to a lot of the same superstions). Going to be exactly 8 guys, cause that's a lucky number, and as soon as their numbers drop to four, the leader immediately kills one of his own grunts, because four is wildly unlucky.
As far as Ares go, I see them as having an evil that is palpable but with understandable, even human motivations. They're ruthless as hell, but they don't strike me as insane. They do evil to profit from it, not for the sake of evil or in service to some greater evil entity or agenda. I figure if you get caught by Ares, they'll be like "You aren't supposed to be here and letting you live is a security risk," and then shoot you. I figure MCT would be like "You have tried to steal from us and now you will die by inches, but first we will need a list of your closest relatives."
I would LOVE to hear more about what Horizon and Evo are into, because that sounds downright creepy. On a similar note, what's the deal with Gary Cline? Not being too familiar with canon, I don't feel so bound by it. I was going to cast him as the archvillain in my game, acting in private a lot like Handsome Jack from Borderlands, with an ultimate goal of creating a global cult of personality around himself. I dunno, I like that idea, but if there's something darker or more interesting in canon, I'd love to hear it.