I wouldn't allow a distance strike nerve strike combination in my game. It becomes too powerful and the idea of nerve strike is that you are hitting the nerve and causing paralysis so I can't see that working from a distance.
From a game balance perspective, my first thought was that they shouldn't combine, either. On the other hand, assuming three IPs, Joe Adept is attacking with a maximum of 12 dice (if you pay 25 BP for Agility and take your one starting level 6 skill in Unarmed Combat). Jane Street Sam, also with three IP, is potentially defending with quite a few more. To take the sample character from 4A, she's defending at 13 without being particularly specialized. It takes a total of four net successes to drop Jane completely. Even worse, her own "unarmed" attacks come with superhuman strength and a spur behind them. With an average of two hits on damage resistance (12 dice of body+armor), Joe is taking 5P per hit after (impact) armor. So even replacing Nerve Strike with direct combat boosters, your specialized unarmed Adept looks to me like so much meat against a Sammie. I guess it pays to pack a sword.
Unfortunately, the other side is true, too. Joe Adept with his two IP, Nerve Strike and Distance Strike is going to flatten Jane pretty quick, especially if he spends edge. Her options are basically full defense or paralysis until that third IP that Joe can't afford anymore, when she can open up.. So in the sense of a starting Adept against a similar starting character, neither option is balanced.
Sure there are options to uneven the odds but they work just as well for the Sammie as they do for the Adept.
On the idea of phantom negative stats to prolong knockout: its not so much a matter of in your face combat as sneaky ninjaness. If Joe can paralyze Jane and keep her knocked out for a long time, then he can stuff her in a closet somewhere and carry on without necessarily alerting anyone. Of course I suppose once she is paralyzed, you could just club her in the head repeatedly, feed her laes or narcojet or spray paint her cybereyes black.