I'd say it's a distinct possibility, rolled with Unarmed Combat like other melee cyber-weapons. There's nothing in the rules saying it's impossible.
As far as toxins go, you aren't going to be injecting someone with tear gas, but there are other chemicals in Core, Stolen Souls, and Run & Gun, last I checked.
By the way, though, you could just conceal a slap-patch inside the compartment and smack it onto someone, thus avoiding the problem to an extent.