Anything will work....you just have to put in a little imagination to make all the pieces stick together.
For more interesting or supposedly impossible to game worlds, read Gurps Infinite worlds for more info. Heck maybe in a GURPS Infinite worlds campaign, Shadowrun would be an alternate earth probably designated by Homeline as:
Merlin-4 Current Year 2030 AD. TL: 9. Mana level: normal/some places high. Great Powers(Japanese Empire CR 4 for Japanese home islands, 5 for occupied territories, 6 for Metahumans), Aztlan CR 5, UCAS CR 3). Infinity class: Z3. Centrum Zone: RED.