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It's not just an absence of knowledge. To take a specific incident: if the Dragon Aden isn't around, he doesn't demolish Tehran. That means the jyhad against metahumans continues. (Also, given real world sex-selection abortions have changed the male-female ratio in India and China, meta-selection abortions in the 6th world would probably obliterate the metahuman populations in these nations).
Ditto the eradication of Down's Syndrome in Iceland and Sweden would be replicated for metahumans.
So expect metahumans to have been nearly exterminated.
Spells, not so much of a problem because they fit into the spellcasters worldview. "Spontaneous remissions" are common enough that it would probably be a couple of years before anyone noticed that healing prayers are being answered on a regular basis.
Also, because no one knows that cyberware reduces your magical potential, large numbers of potential magicians will lose their gifts due to implants.
Cyberware may be *encouraged* because it 'cures mental conditions' - the recipient no longer sees auras etc.