It's an opposed test, so it isn't 1 hit = get free. Close Combat + Str vs Close Combat vs Str. You would restrain them if you don't want to risk killing them or incapacitating them. Say they are the extraction target for example, but aren't willing. While removing him from combat and your team takes care of his two body guards, you keep him from running or attempting to harm anyone else. Once his body guards are down, would be a good time to strongly suggest he cooperate from here on out unless he wants to be unconscious/drugged
All other options involve inflicting damage to the target, which could knock them unconscious or kill them, depending on stats and current damage.