Here, take all of this:
<hands zhoul crystal meth, cocaine, crack cocaine, 8oz of whiskey, herion, and a joint>
Now, drink, snort, smoke all that.
<stands back, starts watch>
In about 2 minutes you'll feel you're on top of the world.
In 20 minutes you'll be doing the funky chicken on the ground.
In 23 minutes you'll be dead.
People OD on drugs of ALL sorts at an alarming rate. I can't find it anymore, but I remember reading at the LA hospitals see about 500 cases of overdosing a DAY!
Heck, thanks to some really bad heroin in the BC coast and 70 OD deaths in 5 days, they issued a public service announcment here just last week.
Now, I havn't seen the drug rules yet (and won't till the physical book comes out) but I would expect mixing drugs to get lethal right quick!
In fact, in BC the 2 biggest drugs are Pot and booze. What a lot of people don't seem to get is that this is actually a VERY lethal combination! Normally when you drink, you will usually reach a point where you just can not drink any more, and you body starts rejecting the alcohol. (IE: you're shit faced, and start vomitting).
However, THC retards your vomit reflex, thus allowing you to keep that full belly of booze, and even continue to drink! And.... you get alcohol poisoning.
It happens so much here in BC that we even have a name for it:
"Green alcohol poisoning"