Chrome Flesh makes drugs feasible as a central theme for a character build. After looking through the rules, I decided to try building a drug-focused street sam. I figured he'd be a little subpar, but with fun flavor. Ended up going priority A attributes and Priority B resources, since drugs are so much cheaper. Bought some low-rating cyberware as a foundation for his combat prowess then spent a ton of money on designer drugs and a few auto-injectors, took the qualities to make him more addiction resistant, and it turns out he could easily outshine a more traditional samurai once he was all jacked up, which wasn't actually all that expensive.
In a nutshell: 5th ed drugs kick ass.