I actually had a player putting a character together with full Amnesia, who he was describing as sort of the Jason Bourne sort. My plan, though sadly the game fell apart due to scheduling issues, was to fill out the remainder of his negative qualities with exactly this. I figured I'd pass him a note during a session that read something like "Your programming has kicked in, causing you to attempt X", hopefully kicking off a mini-arc where the team tries to figure out what the hell happened and how to fix it, eventually providing the character the chance to buy off the quality.
Of course, this was also a player who I know can take things like this and make them freaking gold.