Basically, nanoware in general has started to go haywire. Nanoforges going on the fritz, things produced by nanobots turning out to have major structural flaws, and so on. And then you have the fact that apparently there is either a group of AIs or entropic resonance entities who are using nanoware as a 'bridge' to bodysnatch people.
That is part of the reason cyberware shot up in price, because they had been using nanobots to do all those little nerve connections, and now they have to do it the old way.