Bind (Street Grimoire p.113) starts with a Spellcasting + Magic vs. Body + Strength Opposed Test. The target's Agility is reduced by the caster's net hits. Even if you don't reduce the target's agility to zero, that's still essentially a dice penalty to all Agility-based tests, equivalent to Chaos (SR5 p.290). And if you succeed in reducing the target's Agility to zero, they're effectively neutralized except for purely mental actions.
Attempting to break free is a Strength + Body vs. Force x 2 Opposed Test. Those odds usually favor the spell.
I don't think you can accumulate net hits with repeat spellcasting, but you can recast it and try for a better result.
Petrify (Shadow Spells p.22) is probably a better choice for neutralizing a single target, but Bind leaves them able to answer questions without dropping the spell, and Net Bind gives you an area option. Bind needs fewer hits than stun combat spells to take down average mundane guards, if you can get enough on the first try.