Oh lord, there're dozens of ways. Depends on what you want to do, really.
Want to make 'em evil? Animal testing triggers quick reactions. Toss in some rabbits that are lumpy with tumors, chemically-blinded dogs, etc, and the players will go from "Meh, just a corp" to, "We're blowing this place into kindling."
Need to make 'em big? The cosmetics industry is big, but spin it as a subsidiary for a beauty empire (Publishes magazines, beauty tips, reviews fashion, heck, has a line of fashion, etc) and you get several angles where they can be re-used.
Need to make them influential? In addition to just having money, they can use their publishing arm and rumormill to savage people. A simple "Whjo's hot, who's not" regular feature or Enquirer-style candid shot-stalking can smear someone's reputation easily while good photo ops (Swing by our soup kitchen, go on our fashion shoot to remote backwater with gorgeous coast and take a few shots helping the starving kids there) can build someone up.
Scads more. What do you want to do, then we can figure out the how.