I believe that Laes while natural is from an awakened plant and so could not be produced in a normal metahuman's cybergland. No ruling on whether an awakened metahumna could make it. My characters usually stick with soothsayer or gamma-soccaline for the gland.
As for the lipstick, most assume, that yes it comes with a set of barriers (Maybe a two-sided stick, one a barrier, the other the chemical or stick and brush like lipsticks and sealers) to allow you to use it without being dosed yourself. Getting immunity to most useful drugs seemed difficult unless you went with a surge trait.