The animation style for ASD was too distracting to me. I find it works best with those investing commercials and not for a whole movie. To this day I still couldn't tell you what it was about, aside from being a drug story.
P. K. Dick likes to work with the subject of identity a lot. A Scanner Darkly was about identity and the physical mind - how much of your identity is just a part of your neural wiring. He explored this, naturally, through heavy psychedelic drug use and a protagonist who was in the late stages of total mental degeneration. The plot was about an undercover cop investigating this drug, and using the drug to the point where his mind was literally split in two. Right hemisphere and left hemisphere had severed their connection and he had begun to become two different people where one hand didn't know what the other was doing. In the end, he lost his mind completely and in doing so he was used by the DEA to infiltrate the treatment centers, which were actually pushing the drug.
Dick always has weird endings that sort of flip in subject/style. I think that the centers/farms that create the drugs to create the addicts to work the farms to create the drugs, represent something more significant than what their minor part in the story would suggest. They represent a sort of occluding force over all of society which keeps an individual from true self knowledge through soaking it in confusion and pleasure.
Dick was a fan of the philosophy of Guy Debord, so the idea of a self-perpetuating illusory world which we inflict on ourselves is another of those reoccurring themes in his work.