Love SR4 to death. Has become my favorite system, though I wouldn't try to port it to a different universe, wouldn't work de-cyberpunked.
Streamlining in dnd4e comes from realizing that it's a keyword system. If you want to know how to things interact, look at the keywords, they tell you everything about that item and its interactions with anything else in the game. In this sense, it is very streamlined. Once you really get that concept, everything falls into place. Honestly didn't feel like WoW once we started playing (looked like it when we just read the rules, though).