Ok so Jayde Moon asked a couple times for opinions in a case by case breakdown. Here's mine. Starting with some basic facts about nature of the drugs from SR5 and CF:
Bliss- opiate from poppy plants
Cram-unspecified stimulant
Deepweed-awakened
Jazz-unspecified stimulant
Kamikaze-“tailored combat stimulant”
Long Haul-“hormones and other brain-regulating chemicals”
Nitro-unspecified but powerful stimulant
Novacoke-derived from coca/cocaine
Psyche-“designer stimulant”
Zen-unspecified hallucinogen
AEXD- biomedical TLE-X drug
Everyday Pharma (CF 176) - all cases unspecified
Aisa- unspecified “party drug”
Betameth-a "pseudomethamphetamine"
Betel-betel tree
Cereprax-nootropic
Dopadrine-anti-psychotic
eX-“party drug”
Forget-me-not-unspecified
G3-ginseng, guarana, gingko + vitamins & additives
Guts-unspecified
Hurlg-160-180 proof alcohol w hallucinogenic quantities of nutmeg
K-10- “kamikaze times 10”
Memory Fog-Awakened
Nightwatch- eyedrops “inspired” by eyes of deep sea fish
NoPaint- topical novocaine gel
Oxygenated Flourocarbons-oxygenated fluorocarbon compound
Push-theobromine (cacao seeds) and cathinone (khat)
Red Mescaline-unspecified but compared to peyote
Ripper-synthetic steroids, pseudolipids, sugars, and amphetamines
Slab-unspecified (Reaper-awakened)
Snuff-ancient formula. THC, nicotine, salicin.
Sober Time-unspecified
Soothsayer-“mixes several different plants”
Woad-synthetic hallucinogen
Zero-unspecified immunosuppressant
Zone-unspecified
So what's in and out is going to begin with categorical questions. 1) I'm going to presume that everything starts "in" and has to be eliminated. And furthermore: 2) everything awakened is excluded. 3) The description for Chemical Glands (CF 112) states explicitly that nothing synthetic is applicable. 4) It further says the chemical must be naturally occurring but doesn't specify whether stuff grown by plants counts as "naturally occurring" in a metahuman context.
So if I use all of the above and interpret #4 as meaning "gotta not be said to have a non-metahuman origin" the list of acceptable drugs appears to be:
Cram, Jazz, Kamikaze, Long Haul, Nitro, (Psyche), Zen, AEXD, Everyday Pharma, Aisa, Cereprax, Dopadrine, eX, Forget-Me-Not, Guts, (K-10), {Nightwatch}, (NoPaint), (Oxygenated Flourocarbons/P4MO), {Red Mescaline}, Slab, Sober Time, Zero, Zone.
Stuff (in parenthesis) means it's questionable on passing #3: not being synthesized. Stuff {in braces} are debatable about whether they pass a no-foreign-to-metahuman-dna interpretation of #4, but on my list anyway as there's no explicit grounds for elimination.
Adding to this list if #4 is instead interpreted to include naturally occurring compounds from outside metahuman biology:
Bliss, Novacoke, Betel, (G3), Hurlg (if you can take Hurlg, not sure you wouldn't rather just drink it instead, but hey whatever), Push, Snuff, (Soothsayer)
Again, stuff (in parenthesis) is on my list but only dubiously satisfying tenet #3 for inclusion. They're in because they're not explicitly eliminated (tenet #1)