Ming is correct.
At the time of casting, line of sight to the target is needed. Once the spell is cast and sustained, Line of sight to the target is no longer needed. HOWEVER, to move a area effect sustained spell (like Chaotic world, or Orgasm) The mage must be able to see the area that the spell is to move through AND to.
At Odsh:
Even with a sustaining Foci, there is an upper limit to how long a mage can sustain a spell. Which is the limit of his endurance, once he can't concentrate, the spell stops.
(AKA when he goes to sleep) so really, the upper limit to a sustained spell is 2 to 3 DAYS. After which the human mind is such a mess it can't maintain concentration.
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(And don't even THINK about trying to say "well he can just concentrate while he sleeps!" It never ends well when people try that logic fallacy)