So I had the opportunity to GM this Mission with my new group of players.
I felt it was a pretty good introductory scenario to SR5, as it contains a bit of everything: combat, matrix, magic, legwork, and creepiness. It took us two evenings (something like 5 hours in total) to go through it, but that's mostly because we spent a lot of time checking the rules. Several of my players were familiar with SR (mostly SR3 and 4) and they felt SR5 was an improvement over previous versions. The limit system was especially praised, as was the overall brutality of fights.
Below are some comments on how the Mission was played.
[spoiler]It was a home game so I took the liberty to make a couple of modifications to the scenario, mostly to manage the flow and rhythm since it was cut in two separate sessions: for instance I only put the two mundane guards in the airport scene, and used the mage later (during the second session), as a crazy homeless dwarf squatting the Janus building.
I was hoping to use the sniper scene as well, but I decided to keep it for a future adventure. My plan was for the runners to actually run into a Lone Star operation in Garfield Park, as the cops were basically trying to end Quaid's killing spree. It would have been more a question of sneaking/negotiating past the Star to reach the hidden module than actually engaging Quaid himself. But I felt adding this encounter would have been too much for this particular adventure and ultimately bad for the flow, so I didn't use it in the end.
By the end of the story, my players had a lot of questions and they sure hope to get some answers in future Missions. They also didn't discover that it was actually Shiawase that owned the Janus labs. All they found in the host was the fact Janus was a subsidiary of "Hephaestus Technologies". They do suspect S-K was never the legitimate owner of the labs, but to them that's the usual foul play between corps.
One interesting theory they had, after finding the footage of Sam's evasion, was that it was actually the gestalt of clones that had staged her escape and blocked the cranial bomb's signal.
One player was not too keen on letting Nick Ryder get Samantha. His first reaction was "if the girl is on run, no way I'm giving her to a damn cop." Which struck me as a reaction a lot of shadowrunners would probably have. He changed his mind, although reluctantly, when he realized Sam had been taken from her parents as a child and that Ryder was probably her best bet to be reunited with her family.[/spoiler]