In two years of playing a game every 2 weeks, I have yet to use Unwired. So, unless you are likely to have lots of Matrix stuff going on, you don't need it. You can run with just the core book, but Arsenal and Street Magic add lots of flavour.
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Thats good to know, and I'm not even sure how much our group will get into the hacking side of things though.
And we'll definitely be adding more books once we get the hang of the basics