You were kind of vague with mad doctor, so here is a barrage of ideas I had.
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General tips for character creation
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Spend 160BP-200BP on physical and mental attributes [200BP is the maximum].
Never purchase the last maximum point for an attribute or a skill. Having a few dice missing from a maximum dice pool won't hurt you in the short term. The extra fifteen build points you spend on that last point could be spent on a lot of other things. Remember that an active skill specialization is only 2BP and gives a +2 dice pool modifier.
1BP = $5K -> 15BP * $5K = $75K -> Drones, Guns, Armor, Vehicle + Guns, Fake IDs, Software, Kits/Shops. 12BP is a contact with connection 6 and loyalty 6.
Chemistry is good for drugs and poisons, but it's also great for explosives. For $100K you can buy a chemistry facility and make huge batches of explosives at once.
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Meta Type:
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Cyber Zombie: Normally players can't go below 0 essence. Cyber zombies can go to -6 essence. They all have extreme psychosis and need freak science and magic to hold their bodies together.
Cyborg: A rigger's brain inside housed inside of a drone permanently. They all development mental disorders without therapy.
Ghoul: Eats human flesh.
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Magic
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Adept: Take the ability that raises your non combat active skills for cheap [cybertech, medicine, chemistry, and finally demolitions which is a technical skill]. Make extremely high grade equipment and bank role your team.
Magician: Invest in detection spells like mind probe, mind link, detect lies, and detect truth. Play the role of creepy stalker/therapist/investigator/sociopath who forces people to (re)analyse their lives. Play a ghoul as your race and you have Hannibal Lecter.
Mystic-Adept: Combine both from above.
All the above could also be a toxic shaman/magician on top of this. A toxic shaman being someone who thinks the world is too crowded/polluted/evil/good/sane/insane/weak/powerful/blah/blah, and wants to hit the reset button on humanity.
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Matrix
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Right now corps are raping technomancers to find out about their condition. You could be a psychotic technomancer that relies on Dissonance instead of Resonance. Dissonance is pure chaos and noise. This is the techno version of being a toxic shaman/magician.
Ultra violet servers: By designing and building both a high grade server and sophisticated software you would have a node that was hyper realistic. Seconds in meat time could be decades in node time or vice versa. Become the Architect of your own Utopia/Dystopia/Delusion, Muwhahahaa!
Crash 3.0 virus: Ask your GM if you can make a Software + Logic (16-160, 1 month) extended test. That could probably build you something that could take down the global matrix.
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Meat
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Skill wires: Invent a really popular skill wire system. Hard wire all the skill wires together through some sort of bot net. Execute order 666. Watch everyone who has the system installed take over the globe with your programmed instructions.
Nano robots: Grey goo.
Meat Virus : As above, ask your GM if you could make a Biology + Logic (16-160, 1 month) extended test.