Mass Effect isn't even close to Eclipse Phase's droppings. It's basically a starwars-esque, and a poor fantasy-themed one even. Everything about the series screams 'I'm just a Baldur's Gate descendand iiiin spaaace!'
Sorry, but I just don't get the whole thing. It's a bad, bad attempt at s-f, totally human-centric, with one race to serve as fanservice, and others being basically just DnD racial archetypes.