Right now I'm in a Deathwatch campaign, which easily includes Dark Heresy and Rogue Trader. Shadowrun is in the que as is Warhammer Fantasy Roleplay 3.
I really like Scion, old Vampire the Masquarde, but enjoyed the new Mage and Werewolf. Played in a year long D&D 4 ed. and could not tell you if it is any good or not. I liked Eclipse Phase. My 7th Sea and Legend of the Five Rings collection is small, but well placed in my heart.