I see a lot of runners making a mistake with their so-called "safe house". It's obviously not a safe house but a headquarters - an expensive and permanent HQ. An HQ is just a nice fat, juicy, surface to air missile target for enemies more powerful and more sneaky than you could reasonably deal with. It's called Shadowrun for a reason.
Real safe house ideas>
1. Davy Jones Locker. A strategically placed, fully stocked, waterproof storage container sunk up river from the bridge where you jump your Suzuki Mirage during a dramatic high-speed chase. Just add a retractable remotely operated cable to drag you there and apparatus to ensure you have breathable air for a month and you're good to go.
2. Grandma's. No, not YOUR grandma. Just an old homeless lady with most of her mental facilities left. You throw on a magic disguise, introduce yourself as her long lost nephew, and graciously put her up in a medium lifestyle apartment in another town. You keep the Nuyen flowing for food, rent, trid and drop by once in a while to maintain your role with her and the neighborhood. When the drek hits the fan, of course grandma will take you in. And if necessary your five weird looking poker buddies. Just keep your feet off the furniture and be nice to the cats.
3. Road Trip. Get another storage container, fully stocked. Put a label on it such as "toxic manure". Contract random truck companies via the matrix to haul it randomly throughout North America on secondary roads. You might even send it on a slow boat to China. Once there, get rejected by customs and get a slow boat back.
4. Dirt Nap. Buy a mausoleum "to replace the old family plot which is flooded or full" under a fake SIN. Stock it with coffins full of supplies. Get inhumed when the drek hits the fan. In this option you can add alarms, matrix connections, security cams, even guards. Gotta keep the ancestors safe from ghouls after all.
5. Temp. Work a deal with a Johnson to get a job nights at a distant Stuffer Shack (like Neo Tokyo) in lieu of payment, date TBD, under a fake SIN. Rotate to different coffin hotels. Practice: "Do you want soy fries and flavor packs with that?".
6. Shell Game. Set up all five of these options. Choose one. Monitor the other four. If one gets raided it will tell you volumes about your communication security and/or friends. Admittedly this is only an option for a well heeled runner.