Agreed on hard mode, agreed on it not being impossible. My first character was an unaugmented, non-magical ork and he did okay-- started out as Philip Marlowe, ended up as James Bond. For me it was all about being skilled, being cautious, and taking a lot of free actions to fall flat. Once my stats and skills were bought up with karma, most other characters thought I was a starting phys ad, which is not the worst thing in the world.
Unlike mages, who have to put most of their karma into their magic (initiation, spells and bonding stuff), your karma is just going into skills and stats. And unlike augmented characters, your money isn't going into internal 'ware, but external gear.
At character creation, look at where your BP's are going to go. In the short term, this is the role your character is going to play. I'll assume you're putting as many BP as you can into your stats. Since there's no magic or 'ware to be bought, everything left over is going to be divided among skills, gear and contacts. I like skills, so my feeling would be to take a lot of them. You're not going to get as many actions as other people, so you might as well be as effective as possible when you do act. If you want to start with a lot of gear, that's fine-- my take on it is if you aren't spending your pay on foci or 'ware, you'll probably be able to buy up gear later. This is also a good character type to invest in contacts with, since it's always useful to know people.
My experience is you aren't going to start out as the most effective character in any one role, but you may be the back-up guy in a lot of different roles. There are a lot of ways to contribute beyond multiple IP's or magic. With a high INT, Perception and the right gear, your pool to notice things will be pretty good-- and noticing things is always nice. You can be a decent face without magic or 'ware too. Good stealth and some technical skills will make you a B/E specialist.
Qualities, off the top of my head: Sensitive System. If you're never planning on taking cyberware it's not a bad one, and without magical ability it's not like you aren't sacrificing for the points.