Some general tips: Yes definitely treat it like a buffet, in that you can skip nights, you can pick a later night and do it earlier, you can combine nights, but you have to read the whole thing first and plan accordingly. They're going to introduce a new gang and new npc's almost every night, so being aware of stuff like The Triple during the first few nights if you settle in Cabbagetown is important and helpful. Knowing what's coming will also help you plant seeds for later events and makes the introduction of some nights more organic, like making people in the players' base/village get sick before night 12. Town building is a good way to get the players invested in the area they're settled in. When you start, the players are the ones doing the heavy lifting to help out the community, like Night 3; keep them invested by threatening the community. Later, get them to hire gangs to do the day to day work and transition their involvement to more admin decision making while they go off and do more important jobs.