Jack, i'm going to have to disagree. One-dimensional types like Humanis are good for temporary challenges, and the same goes for the government, or the mafia, or whatever. As Mel Gibson's character says in Payback, you go up high enough, it always comes back to one man. Like I said, Brackhaven is a villain, but Humanis is a problem, complication, or (depending on your group) an asset. (Witting or unwitting is besides the point.) You have to have depth to them before they can become villains. Random Gangster #23 is nothing but a speed bump for Daredevil, but the Kingpin, now HE is a villain. Same with the bugs. Crazy insect shaman isn't a villain, until they start preying on people and building a hive, and trying to bring over a Queen.
Large, one-dimensional threats only work as more than a speed bump if they eventually refine down to one person that the team can take on, or they are massive things that are way beyond the group's pay grade, and the focus of the run becomes running away and getting out from under. To continue with the bug analogy, a hive refines down to the Shaman or the Queen. Take them out, and the threat is either neutralized, or made a great deal less. The Universal Brotherhood, on the other hand, is far too massive for any runner team to hope to take on, and so your only hope is to get out from under, and hope you cover your tracks enough that they don't come after you and yours.