I'd say the shifter thing is pretty major
Agreed, and I would like to add a few suggestions as far as the re-introduction of the Shifter Powers and Weaknesses go. Firstly, since space in a chart is usually at a premium, I would suggest avoiding a huge list like that being added to every single variety of shifter. Adding an extra paragraph to the "Creating a Shapeshifter" section should let you list out all of the powers that all of the Shifters share in one swift and concise way. There's even space on Page 103 if you wanted to add it as a sidebar (or for the text to spill over). If you were to do that, moving the "Shift" power to that section would also save you some space too.
I know it was a thing in previous editions, but it might also be worth mentioning that some variants of Shifters are weak against different metals/materials rather than Silver. It was part of the sidebar in 4th that allowed Shifters of non-human metahuman forms, so it would be worth mentioning separately in this edition.
Finally, unrelated to Shifters:
"Power foci live up to their name. They are very powerful foci that temporarily increase your effective Magic rating.
That means they add to your Sorcery, Conjuring, and Enchanting dice pools, along with any other test where
Magic is involved. Power foci can take any form, but for some reason, rings and amulets are quite popular." SR5 p319
Does this mean they increase your Magic rating for the purposes of whether Drain is Physical?
One assumes they don't increase it with regards to focus addiction rules?
Since it just came up (again) in the rules forums, I thought it might be worth mentioning again for the errata crew. A clarification of what Power Foci are intended to do. I have quite a bit to say, but I'm going to post it to the other thread to keep discussion on that topic.