Yes, the biggest problem with doing Shadowrun in any other system would be Matrix rules. That said, I think Hero System or Mutants and Masterminds would do the best job of it. Both point buy systems, both extremely flexible. If you grab the Star Hero rules for Hero System, you already have some advanced computer rules that give you a springboard to adapt from. But in general, magic, ware, and races are easy to recast in any point-buy system, or even D20. The Matrix is hard to do, since there isn't anything quite like it elsewhere. Heck, give me a couple hours, and I could recast Iceblade from SR to Hero System without much problem. Hero even has Contacts, so that's another leg up. But it would NOT be simple translating the matrix over. Riggers would also be problematic. Probably only have one or two drones, though they would be more powerful than the fleets you can see in shadowrun.