Latest errata for Street Grimoire (circa 09/24/2014 via
here), here's what I've got on a small battery of spells (note that all are Direct spells):
* Manaball - Type M, LOS (A), Damage P, Drain F; affects all living things indiscriminately, including all spirits and shedim possessed corpses; inanimate objects are left alone
* Stunball - Type M, LOS (A), Damage S, Drain F; same as Manaball, but is gentle about it; inanimate objects are also left alone
* Powerball - Type P, LOS (A), Damage P, Drain F, blasts everything in the area without a care in the world, spirits, ghouls, gangers, your best friend's favorite motorcycle, etc.
* Insecticide [insect spirit] - Type M, LOS (A), Damage P, Drain F + 1; limited to affecting one type of insect spirit only (wasp, roach, ant, etc.); at least you don't have to also include Caretaker, Nymph, Scout, Soldier, Worker, or Queen/Mother
* Slaughter [metatype/species] - Type M, LOS (A), Damage P, Drain F - 2; affects one metatype or species only (orks, centaurs, wolf shifters; arguably includes specific HMHVV infected like ghouls & vampires, and specifically included all spirits in general & all dragons in general as options in the previous edition); note it too leaves inanimate objects alone
* Destroy [Free Spirit] - Type M, LOS, Damage P, Drain F - 3; included for comparison, and an extremely specialized spell as it will work on only one singular free spirit in the whole metaverse; by the pattern of spells, Drain F if you wish to make this an area effect to make it easier to hit your singular prey; this includes Queen/Mother insect spirits as they are specifically noted as being free spirits (tread carefully, as this spell does count as a copy of the spirit's formula).
* Magebolt - Type P, LOS, Damage P, Drain F - 4; also included for comparison (from Shadow Spells), and by patterns of other spells Drain F - 1 for an area version; affects only Awakened and/or the dual natured, so will indiscriminately affect all spirits of all types so long as they're actually materialized or inhabiting/possessing someone/something. Also useful for those pesky HMHVV infected or blasting dragons (if you're truly looking to kill yourself).
Based on the information I have, Slaughter is easiest on the drain compared to its application, and arguably a much more broadly effective spell against spirits in general than Insecticide as it's usable against all spirits, which would also include blood, toxic, shadows, and shedim as well as insect and your basic spirit. Maybe even watcher spirits as well ("walks like a duck..."). Of course, this will affect your own spirits at the same time if they're caught in the area of effect.