[The Wyrm Ouroboros]

... you are a mean, cruel, nasty GM.  I like that; I like it a lot.  And I'd probably make it martial arts - since the employee will always have their body, and a handy taser/firearm is just a PO'd employee waiting to happen.

[Emil_Barr]

Just because theyre now trained combatants doesnt meant theyre willing to engage in a fight. After all, they arent exactly paid for this. Youd need some sort of way to compel them into action. I suppose you could inject them all with drugs, like was said, but Id think anything that would make them sufficiently aggressive to attack people would make them just as  likely to butcher eachother as it would any intruders. Not to mention the property damage unleashed by a horde of now berserk people who were probably quite unhappy with their corp life as it was.
.
Maybe Im just over thinking it.

[Csjarrat]

Yeah, that might be better represented by persona-fix chips tbh

[Leevizer]

Extensive social programming ("Our corp good! Other corps bad! Shadowrunners evil! Corpsec Justice!"), and then either having something extra added along with the skillwires or the aforementioned drug dispensed. This can easily be done with a GM fiat but shouldn't be anything common, I think.

[MijRai]

Bah, don't bother directing them.  It needs to be an insane wuxia smackdown with a horde of office employees going nuts.  Though sadly enough, no nun-chuck telephones, since wired phones don't really exist in the professional workplace anymore...  Or, if you like your initial idea...  Give the decker or technomancer a chance to find out about this security measure, and have them hack it and pre-activate it!  That's one hell of a diversion, if the goal isn't in that room/part of the building. 

[Marcus]

b/c sometimes you need to land a plane, and without Skillwires you don't know how.

[Tenlaar]

Extensive social programming ("Our corp good! Other corps bad! Shadowrunners evil! Corpsec Justice!"), and then either having something extra added along with the skillwires or the aforementioned drug dispensed. This can easily be done with a GM fiat but shouldn't be anything common, I think.

Not to mention just a plain ol' five grand bonus for whoever's registered bullets are found in the intruders' bodies.